James Misko (born June 18, 1970) is an American prelate of the Catholic Church who serves as bishop for the Diocese of Tucson.
On June 9, 2007, Misko was ordained to the priesthood.
Pope Leo XIV appointed Misko bishop for the Diocese of Tucson on December 22, 2025. On February 20, 2026, Misko was consecrated as a bishop and installed as the new bishop of the Diocese of Tucson.