JWH-424 is a drug from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB<sub>1</sub> and CB<sub>2</sub> receptors, but with moderate selectivity for CB<sub>2</sub>, having a K<sub>i</sub> of 5.44nM at CB<sub>2</sub> vs 20.9 nM at CB<sub>1</sub>. The heavier 8-iodo analogue is even more CB<sub>2</sub> selective, with its 2-methyl derivative having 40 times selectivity for CB<sub>2</sub>. However the 1-propyl homologues in this series showed much lower affinity at both receptors, reflecting a generally reduced affinity for the 8-substituted naphthoylindoles overall.
In the United States, all CB<sub>1</sub> receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-424 are Schedule I Controlled Substances.