JWH-047 is a selective cannabinoid ligand that binds to both CB<sub>1</sub> and CB<sub>2</sub>. It has a bindining affinity of K<sub>i</sub> = 0.9 nM for the CB<sub>2</sub> subtype, and more than 65 times selectivity over the CB<sub>1</sub>.
In the United States, all CB<sub>1</sub> receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-047 are Schedule I Controlled Substances.