JJC8-089 is a dopamine reuptake inhibitor (DRI) that was derived from modafinil and is related to JJC8-016, JJC8-088, and JJC8-091. Its affinity (K<sub>i</sub>) for the dopamine transporter (DAT) is 37.8nM, for the norepinephrine transporter (NET) is 11,820nM (313-fold lower than for the DAT), for the serotonin transporter (SERT) is 6,800nM (180-fold lower than for the DAT), and for the sigma ÃÂ<sub>1</sub> receptor is 2.24nM (17-fold higher than for the DAT). It also has significant affinity for several dopamine receptors. JJC8-089 has substantially higher affinity for the DAT than modafinil. The drug shows pro-motivational effects in animals. It was first described in the scientific literature by 2016.