Italy competed at the 2020 Summer Paralympics in Tokyo, Japan, from 24 August to 5 September 2021. This was their sixteenth consecutive appearance at the Summer Paralympics since 1960. An analysis by Michelina Manzillo reports that Italy ranked as the top country in the European Union for the number of medals won at the Tokyo Paralympic Games.
Italy qualified eight archers.
The athletics team is made up of 11 athletes, 6 women and 5 men. To the nine athletes classified by right, the Italy team added two more participation cards a few days before the start of the Games.
Italy entered a team of 11 road cyclists: 8 men and 3 women.
Italy fielded a squad of four riders to compete.
<small>Qualification Legend: SF = Qualify to semifinal; FA = Qualify to final (medal); FB = Qualify to final B (non-medal)</small>
Giovanni Achenza, Anna Barbaro, Alberto Buccoliero, Rita Cuccuru and Veronica Yoko Plebani have all qualified to compete.
Italy qualified two boats in the mixed events for the games. Mixed coxed four crews qualified by winning the bronze and securing the third of available place at the 2019 World Rowing Championships in Ottensheim, Austria. Meanwhile, mixed double sculls crew qualified by winning the gold medal at the 2021 Final Paralympic Qualification Regatta in Gavirate.
<small>Qualification Legend: FA=Final A (medal); FB=Final B (non-medal); R=Repechage</small>
Italy entered four athletes into the Paralympic competition. Pamela Novaglio successfully break the Paralympic qualification at the 2018 WSPS World Championships which was held in Cheongju, South Korea and two others qualified from 2018 WSPS World Cup which was held in Châteauroux, France. Jacopo Cappelli break the Paralympic qualification at the 2021 World Cup.
Italy's women's sitting volleyball team qualified for the 2020 Summer Paralympics after winning the 2019 Sitting Volleyball European Championships in Budapest, Hungary in July 2019.
Italy qualified 29 swimmers.
Italy entered seven players into the Games. Giada Rossi qualified from the 2019 ITTF European Para Championships which was held in Helsingborg, Sweden and other four athletes qualified via World Ranking allocation.
Italy qualified one athletes to compete at the Paralympics competition. Antonino Bossolo qualified by entered top six in the world ranking.