Italy sent a delegation of 86 athletes and 6 guides to compete at the 2008 Summer Paralympics in Beijing. Italian competitors took part in 12 sports: athletics, rowing, cycling, judo, swimming, wheelchair fencing, equestrian, wheelchair tennis, shooting, archery, table tennis and sailing.
|- |align=left|Alberto Simonelli |align=left|Men's individual compound standing |667 |15 |<br />W 112-107 |<br />W 115-112 |<br />W 111-110 |<br />W 116-110 |<br />L 111-116 | |- |align=left|Fabio Luca Azzolini |align=left|Men's individual compound W1 |593 |10 | |<br />W 107-101 |<br />L 97-113 |colspan=3|did not advance |- |align=left|Mario Esposito |align=left|Men's individual recurve standing |631 |1 |Bye |<br />W 101-98 |<br />W 102-95 |<br />L 91-95 |<br />L 93-98 |4 |- |align=left|Oscar de Pellegrin |rowspan=3 align=left|Men's individual recurve W1/W2 |629 |4 |<br />W 107-76 |<br />L 99-101 |colspan=4|did not advance |- |align=left|Antonino Lisotta |556 |25 |<br />L 90-97 |colspan=5|did not advance |- |align=left|Marco Vitale |624 |7 |<br />W 104-99 |<br />W 101-97 |<br />W 102-98 |<br />W 103-101 |<br />L 104-108 | |- |align=left|Oscar de Pellegrin<br/> Mario Esposito<br/> Marco Vitale |align=left|Men's team recurve |1884 |2 |colspan=2 |<br />W 206-202 |<br />L 201-208 |<br />W 207-194 |
|- |align=left|Elisabetta Mijno |align=left|Women's individual recurve W1/W2 |519 |11 | |<br />L 94-98 |colspan=4|did not advance