Italy competed at the 2004 Summer Paralympics in Athens, Greece. The team included 76 athletes, 62 men and 14 women. Competitors from Italy won 19 medals, including 4 gold, 8 silver and 7 bronze to finish 31st in the medal table.
|- |align=left|Daniele Cassiani |align=left|Men's individual W1 |386 |12 |N/A |<br />L 114-164 |colspan=4|did not advance |- |align=left|Salvartore Carrubba |align=left rowspan=3|Men's individual W2 |555 |29 |<br />L 126-155 |colspan=5|did not advance |- |align=left|Oscar de Pellegrin |626 |2 |Bye |<br />W 151-147 |<br />W 94-91 |<br />L 97-98 |<br />L 96-104 |4 |- |align=left|Marco Vitale |568 |24 |<br />W 153-137 |<br />L 139-158 |colspan=4|did not advance |- |align=left|Salvatore Carrubba<br/> Oscar de Pellegrin<br/> Marco Vitale |align=left|Men's team |1749 |10 |N/A |<br />W *197-197 |<br />L 223-226 |colspan=3|did not advance
|- |align=left|Paola Fantato |align=left rowspan=3|Women's individual W1/2 |570 |4 |N/A |<br />W 154-127 |<br />W 85-80 |<br />W 96-88 |<br />W 97-83 | |- |align=left|Anna Menconi |514 |14 |N/A |<br />L 128-129 |colspan=4|did not advance |- |align=left|Sandra Truccolo |533 |12 |N/A |<br />L 117-119 |colspan=4|did not advance |- |align=left|Paola Fantato<br/> Anna Menconi<br/> Sandra Truccolo |align=left|Women's team |1617 |6 |colspan=2|N/A |<br />W 201-176 |<br />W 205-194 |<br />L 157-184 |
The men's wheelchair basketball team didn't win any medals; they were 6th out of 12 teams.