Istrinsky District () is an administrative and municipal district (raion), one of the thirty-six in Moscow Oblast, Russia. It is located in the western central part of the oblast. The area of the district is . Its administrative center is the town of Istra. Population: 115,753 (2002 Census); The population of Istra accounts for 29.3% of the district's total population.
The Istra River flows through the district.
Alyokhnovo is one of the rural communities in the district.