Issaquena, also known as Valley Plantation, is an unincorporated community in Sharkey County, Mississippi, in the United States.
"Issaquena" is a Choctaw word meaning "Deer River". The community was named from Deer Creek upon which it is located.
Issaquena is located on the former Illinois Central Gulf Railroad.
A post office operated under the name Issaquena from 1913 to 1921.