Isolabona () is a comune (municipality) in the Province of Imperia in the Italian region Liguria, located about southwest of Genoa and about west of Imperia. As of 2011, it had a population of 716, spread between 333 families throughout an area of .
Isolabona shares borders the following municipalities: Apricale, Castelvittorio, Dolceacqua, Pigna and Rocchetta Nervina.