Isola Sant'Andrea Lighthouse () is an active lighthouse located on a flat islet, the Isola Sant'Andrea, positioned at from Gallipoli on the Ionian Sea.
The lighthouse was built in 1865 and consists of a white octagonal prism tower, high, with balcony and lantern, rising from a 2-storey white keeper's house. The lantern, painted in grey metallic, is positioned at above sea level and emits two white flashes in a 10 seconds period, visible up to a distance of . The lighthouse is completely automated and is managed by the Marina Militare with the identification code number 3562 E.F.