Isola (; ) is a commune of the Alpes-Maritimes department in southeastern France.
The Alpine ski resort of Isola 2000 is located on the territory of the commune.
Isola has a subarctic climate (Köppen climate classification Dfc). The average annual temperature in Isola is . The average annual rainfall is with November as the wettest month. The temperatures are highest on average in July, at around , and lowest in January, at around . The highest temperature ever recorded in Isola was on 19 July 2023; the coldest temperature ever recorded was on 4 February 1978.
Since April 2010, Isola has been officially twinned with Castiglione di Garfagnana.