The brain sponge (Isodictya elastica) is a species of marine demosponge in the family Isodictyidae. This sponge is known from the west coast of South Africa to Port Elizabeth. It is endemic to this region.
The brain sponge may grow to across. It has a smooth surface, covered with many scattered oscula. It may be beige to pink in colour and grows in two forms: one massive and convoluted, rather like a brain, and the other with narrowing fingers. Its texture is soft and compressible.
This sponge lives on rocky reefs subtidally to .