Isis Central is a rural locality in the Bundaberg Region, Queensland, Australia. In the , Isis Central had a population of 205 people.
The locality takes its name from the Isis River, which in turn was named by mine owner William Howard who lived in the area from 1862. Howard named it after the Isis River in England, a tributary of the River Thames.
In 1894, local sugarcane growers decided to raise funds to build the Isis Central Sugar Mill. The Queensland Government approved the construction of the mill, costing ã26,000 and Walkers Limited were engaged to build the mill. The first crushing began on Tuesday 7 September 1897.
Isis Central Mill Provisional School opened on 23 January 1899. It became Isis Central Mill State School on 1 January 1909. It closed on 11 December 1987. It was on the north-eastern corner of Kevin Livingstone Drive and Madsens Road ().
In the , Isis Central had a population of 216 people.
In the , Isis Central had a population of 205 people.
There are a number of heritage-listed sites in Isis Central, including:
There are no schools in Isis Central. The nearest government primary schools are Cordalba State School in neighbouring Cordalba to the north-east and Booyal State School in neighbouring Booyal to the west. The nearest government secondary school is Isis District State High School in Childers to the south-east.