Isfara District or Nohiya-i Isfara () is a former district at the northeastern edge of Sughd Region, Tajikistan, bordering on Uzbekistan's Ferghana Valley to the north and Kyrgyzstan to the south. Its capital was Isfara. Vorukh, an enclave surrounded by Kyrgyzstan, is also part of Isfara. Around 2018, it was merged into the city of Isfara.
The district was divided administratively into jamoats. They were as follows (and population).