Isadora is an unincorporated community in northwest Worth County, Missouri, United States.
Isadora is on Missouri Route A, northwest of Grant City and east of Sheridan. =The community is on the floodplain of the Grand River and is south of the MissouriâÂÂIowa state line.
Isadora was platted in 1863. A post office called Isadora was established in 1866, and remained in operation until 1951. According to tradition, the community was named after the wife of a pioneer man who paid a visit to the area. The population in the 1870s was about 150.