Isabel (IPA: ]), officially the Municipality of Isabel (; ; ), is a First Income Class municipality in the province of Leyte, Philippines. According to the 2024 census, it has a population of 46,858 people.
The town was formally established and created by carving out the villages of Quiot, Santa Cruz, Libertad, Matlang, Tolingon, Bantigue, Apale and Honan from the town of Merida, by the passage of Republic Act No. 191.
Isabel is bounded to the east by the municipality of Merida and to the north by the municipality of Palompon. Nearest landfall south is Ponson Island (Camotes) at about . Nearest landfall west is coastal Tabogon, Cebu at about .
Isabel comprises 24 barangays. Each barangay consists of puroks and some have sitios.
In the 2024 census, the population of Isabel was 46,858 people, with a density of .
Leyte Industrial Development Estate (LIDE) is a 425 ha special economic zone in the industrial town of Isabel. It currently has 2 locators: PASAR(Philippine Associated Smelting & Refining Corporation) & PHILPHOS(Philippine Phosphate Fertilizer Corporation).