Isaac Dion Smith (born October 9, 2004) is an American college football safety for the Mississippi State Bulldogs.
Smith attended Itawamba Agricultural High School in Fulton, Mississippi. He was rated as a four-star recruit and committed to play college football for the Mississippi State Bulldogs over offers from schools such as Florida, Florida State, Georgia, LSU, Texas A&M, and USC.
As a freshman in 2023, Smith appeared in all 12 games for the Bulldogs, totaling 15 tackles. In the 2024 season opener, he tallied 11 tackles and a pass deflection in a win over Eastern Kentucky. In week 4, Smith notched seven tackles and a forced fumble through just three quarters before leaving with a concussion, in a loss versus Florida. He missed the following week's matchup with #1 Texas.