Isaac ben Jacob Ḥayyut (died 1726) was a Polish rabbi.
He was descended from an old Provençal family which first settled in Bohemia, and was the grandson of Rabbi Menahem Manesh Hayyut of Wilna.
He became rabbi of Skole, near Lviv, late in life, and remained there until his death.
He wrote thirteen works, which are enumerated in the preface to his "Zera' YiáºÂḥaḳ" () on the Mishnah, which was published by his son Eliezer (Frankfort-on-the-Oder, 1732). His "Iggeret ḲeẠḤai" (Hebrew: ), describing in a kabbalistic manner "terrible things which he had seen in the upper world," was published in Chernivtsi in 1862.
He died at Skole in September, 1726.