Irrewillipe ( )is a locality in south west Victoria, Australia. The locality is in the Colac Otway Shire, south west of the state capital, Melbourne.
At the , Irrewillipe had a population of 125.
Irrewillipe State School opened on 24 January 1870 and was still operating in 1973, closing at an unknown date thereafter.
A Bible Christian Church opened at Irrewillipe on 24 January 1886, became a Methodist church in 1902, and a Uniting Church in 1977. It closed at an unknown date and the building was subsequently sold into private ownership in 2002. It was also known as Holy Trinity Church.