The Irene River is a tributary of the Opawica River, flowing into the Municipality of Eeyou Istchee James Bay (municipality), in Jamésie, in the administrative region of Nord-du-Québec, in Quebec, in Canada.
This river crosses successively the cantons of Fancamp and Rasles. Forestry is the main economic activity of the sector; the recreational tourism activities is second.
The southern part of the Irene River valley is served by the R1032 forest road (North-South direction) and by secondary forest roads.
The surface of the Irene River is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.
At various times in history, this territory has been occupied by the Attikameks, the Algonquins and the Crees. The term "Irene" is a first or last name of French origin.
The toponym "Irène River" was made official on December 5, 1968, at the Commission de toponymie du Québec, when it was created.