Inositol nicotinate

Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements.

Mechanism of action

When ingested, inositol nicotinate breaks down into inositol and niacin. The niacin component helps widen blood vessels (vasodilation), lowers blood lipid levels (including cholesterol), and inhibits a protein involved in blood clotting.

Uses

Inositol nicotinate is used to treat blood circulation problems, including:

• Raynaud's phenomenon
• Intermittent claudication

Some research shows it can improve symptoms of Raynaud's phenomenon over several weeks. However, its effectiveness in treating other conditions like:

• High cholesterol
• High blood pressure
• Leg pain during exercise (due to poor circulation)

remains unclear, with studies producing mixed results.

Other proposed uses, such as for:

• Migraines
• Psoriasis
• Restless legs syndrome

have insufficient supporting evidence.

Side effects

Inositol nicotinate is generally safe when taken by mouth, but possible side effects include:

• Stomach upset
• Intestinal gas
• Nausea
• Liver damage (similar to other niacin products)

It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin.

Precautions

Inositol nicotinate should be used with caution in individuals with certain conditions:

• Diabetes: May raise blood sugar levels. Diabetic patients should monitor their blood sugar levels closely.
• Liver disease or kidney disease: Niacin can accumulate in people with liver or kidney problems, potentially worsening their condition.
• Bleeding disorders: Inositol nicotinate may slow blood clotting, increasing the risk of bleeding for individuals with clotting disorders or those undergoing surgery.
• Gout: Large amounts of niacin may trigger gout attacks.

References