Indian Creek is a stream in St. Francois County in the U.S. state of Missouri. It is a tributary of the St. Francis River.
The stream begins at the confluence of Middlebrook Creek and Mud Creek at . The stream flows north and is impounded as Iron Mountain Lake within the Iron Mountain Lake community. The stream continues to the north-northeast passing under Missouri Route W on to its confluence with the St. Francis River about 3.5 miles southeast of Bismarck at .
Indian Creek was so named on account of a nearby Indian village.