The 16th Independent Spirit Awards, honoring the best in independent filmmaking for 2000, were announced on March 24, 2001. It was hosted by John Waters.
<big>John Cassavetes Award</big>
<big>Chuck & Buck</big>
<big>Truer Than Fiction Award</big>
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<big>Producers Award</big>
<big>Paul Mezey – The Ballad of Ramblinâ Jack and Spring Forward</big>
<big>Someone to Watch Award</big>
<big>Marc Forster – Everything Put Together</big>