ID-4708

ID-4708 is a butyrophenone neuroleptic agent. It has the same structure as for trifluperidol but differs by the incorporation of an aniline amino group into the butyrophenone sidechain.

Whereas trifluperidol is a Belgian drug developed at Janssen Pharmaceuticals, ID-4708 was developed by a Japanese company called Sumitomo Chemical in the 1970’s.

ID-4708 when given at low doses reduced ambulation, while at higher doses defecation was inhibited.

Synthesis

The chemical synthesis of ID-4708 was reported:

• 2-Acetylbutyrolactone [517-23-7] (1)
• 4-Fluoro-2-nitrobenzoic acid [394-01-4] (2)
• 4-Fluoro-2-nitrobenzoyl chloride [57750-82-0] (3)
• 3-(4-Fluoro-2-nitrobenzoyl)oxolan-2-one [62513-47-7] (4)
• 4-Bromo-1-(4-fluoro-2-nitrophenyl)butan-1-one [62513-48-8] (5)
• 2-(3-Bromopropyl)-2-(4-fluoro-2-nitrophenyl)-1,3-dioxolane [62513-50-2] (6)
• 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine [2249-28-7] (7)
• PC86735492 (8)
• PC70620175 (9)

References