Hussein Makhlouf Makhlouf (; born 1964) is a Syrian politician. He is former Water Resources Minister.
Occupied several posts at the Coast Company for Construction and Building and the General Establishment of Construction and Building, and chaired a project for expanding Lattakia port.
Director of Water Resources Department (2006-2011), chairing joint committees with Lebanon, Jordan, and Turkey on water affairs.
He was Governor of the Damascus Countryside Governate from 2011 to 2016. Between 2016 and 2023, he served as a Local Administration and Environment Minister.