John Hugh O'Donnell, C.S.C. (June 2, 1884 – June 12, 1947), was an American Catholic priest who served as president of the University of Notre Dame from 1940 to 1946, after having served as vice president from 1934 to 1940 and as president of St. Edward's University from 1931 to 1934.
During World War II, O'Donnell offered Notre Dame's facilities to the armed forces. The navy accepted his offer and installed Naval ROTC units on campus as part of the V-12 Navy College Training Program. Soon after the installation there were only a few hundred civilian students at Notre Dame. O'Donnell also continued O'Hara's work with the graduate school. He further formalized the graduate program and replaced the previous committee of graduate studies with a dean.