Huff Creek is a stream in western Nodaway County in the U.S. state of Missouri. It is a tributary of the Nodaway River and is 5.9 miles long.
Huff Creek, historically called "Huff Branch", gets its name from Joseph Huff, a pioneer citizen.
Huff Creek is a right tributary of the Nodaway River and joins it 42.5 miles before its mouth in the Missouri River. The entire stream is within Green Township. There are two named reservoirs in the Watershed: Hoover Frankum Reservoir (E-20) and Patterson Farms Lake (Sec. 12), the latter being in Bilby Ranch Lake Conservation Area.
The stream headwaters about one-half mile east of the Atchison-Nodaway County line and flows easterly through the northern portion of Bilby Ranch Lake Conservation Area. It continues east-northeast until its confluence with the Nodaway River just northwest of Quitman.
There is one highway that crosses Huff Creek at Route PP. in Green Township.