Howard Yuan-hao Chang (; born January 11, 1972) is a Taiwanese-American physician-scientist and molecular biologist. He is the Virginia and D. K. Ludwig Professor of Cancer Research at the Stanford University School of Medicine, where he is also a joint professor of dermatology, genetics, and pathology.
Since 2024, Chang has been the senior vice president of research and chief scientific officer of Amgen. He is also a principal investigator at the Howard Hughes Medical Institute. He is best known for his research on long non-coding RNAs.
Chang was born in Taipei, Taiwan, on January 11, 1972, to a family of Taiwanese physicians. He is the son of Taiwanese physician and politician Chang Chau-hsiung, a former chair of the People First Party. When he was twelve years old, Chang moved with his mother and younger brother to Southern California.
Chang graduated summa cum laude from Harvard University with a Bachelor of Arts in biochemistry in 1994. As an undergraduate at Harvard College, he worked in the laboratory of biochemist Christopher T. Walsh. He then earned his Ph.D. in biology from the Massachusetts Institute of Technology (MIT) under Nobel laureate David Baltimore in 1998, after only two years of study.
In 2000, Chang earned his Doctor of Medicine (M.D.) from Harvard Medical School. As a medical student at Harvard, Chang was a member of the HarvardâÂÂMIT Program in Health Sciences and Technology, and won the medical school's Leon Reznick Memorial Prize for excellence in research.
After receiving his M.D., Chang was a postdoctoral fellow at Stanford under Patrick O. Brown from 2000 to 2004. He simultaneously completed his residency in dermatology at the Stanford University School of Medicine from 2001 to 2004.
After starting his own lab, Chang's group discovered unexpected transcriptional activity for noncoding DNA and identified HOTAIR which further confirmed the importance of long non-coding RNAs. More recently, his group has reported multiple discoveries related to mechanisms and functional roles of extrachromosomal DNA in cancer pathogenesis.
Chang is a co-inventor of ATAC-seq, a widely-used epigenomic method introduced in 2013 in collaboration with the lab of William J. Greenleaf.