Muller's velvet gecko (Homopholis mulleri) is a species of lizard in the family Gekkonidae. The species is endemic to South Africa.
The specific name, mulleri, is in honor of South African amateur herpetologist .
Homopholis mulleri is found in the province of Limpopo, South Africa.
The preferred natural habitat of Homopholis mulleri is open veld, where it shelters in holes and under the loose bark of trees such as Sclerocarya birrea and Senegalia nigrescens.
Dorsally, Homopholis mulleri is light brown to dark gray, with darker and lighter markings. Ventrally, it is white.
Females may attain a snout-to-vent length (SVL) of . Males are smaller, attaining SVL.
Homopholis mulleri is oviparous.