Holmes is an unincorporated community in Union Township, Grand Forks County, North Dakota, United States.
Holmes was established circa 1872. Etymology is uncertain, with the settlement either being named after local land surveyor David M. Holmes or Union Township's first clerk Holmes Wyman. A post office was established in 1886; it closed in 1954. The population was approximately 25 for much of its history, centered around a country store which closed in 1962.