Holden B. Mathewson House is a historic home at South Otselic in Chenango County, New York. It is a large, Colonial RevivalâÂÂstyle residence built in 1908âÂÂ1909. It is a -story, frame structure on a rusticated stone foundation, surmounted by a tall hipped roof with gabled dormers.
It was added to the National Register of Historic Places in 2009.