Holcombe is a census-designated place located in Chippewa County, Wisconsin, United States. As of the 2020 census, Holcombe had a population of 239.
Holcombe is located on the Chippewa River north-northeast of Cornell, in the town of Lake Holcombe. Holcombe has a post office with ZIP code 54745. As of the 2010 census, its population was 267.
Holcombe was founded in 1902. It was named for an acquaintance of a railroad official. A post office has been in operation in Holcombe since 1902.