The Italy and South Africa rugby union teams first met in 1995. The Springboks 101-0 victory in Durban in 1999 was at the time their largest victory, and remains Italy's heaviest defeat. Italy earned their first ever win over South Africa on 19 November 2016, 20-18, in Florence.
The teams have met once in the Rugby World Cup, in the group stages of the 2019 Rugby World Cup, with South Africa winning 49-3 after Italy had a player sent off.
<small>Note: Date shown in brackets indicates when the record was or last set.</small>