Ippokrateio General Hospital of Thessaloniki () is a public hospital in Thessaloniki, Greece.
The main building was constructed in 1908 as Hirsch Hospital funded by Maurice de Hirsch (architect Pietro Arrigoni).
During the Axis occupation of Greece it was used by the German army. It was renamed after World War II. Today it is part of the National Health System and is the largest hospital in Thessaloniki.