Hillsboro is an unincorporated community and census-designated place (CDP) in Scott County, Mississippi, United States. As of the 2020 census, Hillsboro had a population of 1,072. Hillsboro has a post office with ZIP code 39087.
Hillsboro is named for its location on a hill above the surrounding area. The community was formed in 1835 and was the county seat of Scott County from 1836 to 1856. Hillsboro formerly had a newspaper, The Argus.
In 1900 Hillsboro had a population of 112, two churches, and four stores.
As of the 2020 United States census, there were 1,072 people, 357 households, and 213 families residing in the CDP.
Most of Hillsboro is in the Forest Municipal School District while a portion is in the Scott County School District.