Henry Street Historic District is a national historic district located at Roanoke, Virginia. It encompasses four contributing buildings constructed between 1917 and 1951. They were developed as the central business and entertainment district for the African-American neighborhood of Gainsboro in Northwest Roanoke. They are the Hotel Dumas (1917), The Strand Theatre (1923), Dr. Lylburn Downing office (c. 1945), and a commercial building (1951).
It was listed on the National Register of Historic Places in 2004. The buildings are also included in the Gainsboro Historic District.