Henderson Run is a long 1st order tributary to Pine Creek in Crawford County, Pennsylvania.
Henderson Run rises about 2 miles west of Dotyville, Pennsylvania in Crawford County and then flows south-southeast to Pine Creek about 1 mile northeast of East Titusville, Pennsylvania.
Henderson Run drains of area, receives about 44.9 in/year of precipitation, and has a wetness index of 433.72 and is about 81% forested.