Heartsease is a historic home located at Hillsborough, Orange County, North Carolina. It was built about 1770, and consists of a -story, three-bay, central block dating to the late 18th century, with an early 19th-century -story east wing, and two-story pedimented west wing added in the late 19th century. It is topped by a gable roof and features a shed porch whose roof supported by plain Tuscan order posts. It is believed that Heartsease served as the pre-Revolutionary home of Thomas Burke, North Carolina's third governor and a member of the Constitutional Convention.
It was listed on the National Register of Historic Places in 1973. It is located in the Hillsborough Historic District.