Haut-Sassandra Region is one of the 31 regions of Ivory Coast and is one of two regions in Sassandra-Marahoué District. The region's seat is Daloa. The region's area is 15,190 kmò, and its population in the 2021 census was 1,739,697, making it the most populous region of Ivory Coast.
Haut-Sassandra is currently divided into four departments: Daloa, Issia, Vavoua, and Zoukougbeu.
The region is traversed by a northwesterly line of equal latitude and longitude.
Haut-Sassandra Region was created in 1997 as a first-level administrative region of the country. In 2000, Gagnoa Department was split off from Haut-Sassandra and combined with Oumé Department from Marahoué Region to form Fromager Region.
As part of the 2011 administrative reorganisation of the subdivisions of Ivory Coast, Haut-Sassandra was converted into a second-level administrative region and became part of the new first-level Sassandra-Marahoué District. No territorial changes were made to Haut-Sassandra as a result of the reorganisation.