Harmon Creek is a long 3rd order tributary to the Ohio River in Brooke County, West Virginia.
According to the Geographic Names Information System, it has also been known historically as:
Harmon Creek rises about south of Florence, Pennsylvania, in Washington County and then flows south and west into West Virginia and Brooke County and briefly turns north into Hancock County to join the Ohio River at the south end of Weirton.
Harmon Creek drains of area, receives about of precipitation, has a wetness index of 326.37, and is about 70% forested.