Handball Club Holon (), is a professional handball club from the city of Holon, Israel. They compete in the Israeli Handball League, within the Israeli first division.
Handball Club Holon was founded in 1972. The club's biggest success in the 2018/19 season was the Israeli Cup final. At the end of a tight and tense match, the team lost to Maccabi Rishon LeZion and finished second in the cup.