Hamilton Smith

Hamilton Smith may refer to:

• Charles Hamilton Smith (1776–1859), English artist, naturalist, antiquary, illustrator, soldier, and spy
• Hamilton Lanphere Smith (1819–1903), American scientist, photographer, and astronomer
• Hamilton Smith (cricketer) (1884–1955), Hampshire cricketer
• Hamilton O. Smith (1931–2025), American microbiologist and Nobel laureate