Haloacid dehydrogenase superfamily

The haloacid dehydrogenase superfamily (HAD superfamily) is a superfamily of enzymes that include phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, and are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification.

Examples

A HAD domain is found in several distinct proteins including:

• Phospholipid-translocating ATPase , a putative lipid-flipping enzyme involved in cold tolerance in Arabidopsis
• 3-deoxy-D-manno-octulosonate (KDO) 8-phosphate phosphatase (), which catalyses the final step in the biosynthesis of KDO - a component of lipopolysaccharide in Gram-negative bacteria
• Mannosyl-3-phosphoglycerate phosphatase (), which hydrolyses mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
• Phosphoglycolate phosphatase (), which catalyses the dephosphorylation of 2-phosphoglycolate
• 5´-Nucleotidase (EC 3.1.3.5) which either catalyzes the hydrolysis of IMP. or IMP and GMP
• Hypothetical proteins

Human genes encoding proteins that contain this domain include:

• ATP8B3, ATP8B4, ATP10A, ATP10B, ATP10D

References