HOT-x, also known as 4-alkylthio-2,5-dimethoxy-N-hydroxyphenethylamines or hydroxylated 2C-T derivatives, are a group of psychedelic drugs of the phenethylamine and 2C families. They have a hydroxy group (HO) at the amine as well as methoxy groups at the 2 and 5 positions and an alkylthio (T) group at the 4 position of the phenyl ring. The HOT-x drugs are the N-hydroxyl analogues of the corresponding 2C-T-x drugs.
The HOT-x drugs were synthesized and tested by Alexander Shulgin and were reported by him in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).
All three of the HOT-x drugs produce psychedelic effects according to Shulgin. The HOT-x drugs are said to be very similar to their 2C-T counterparts in terms of properties and effects and may act as prodrugs to these compounds.
The HOT-x drugs are controlled substances in Canada under phenethylamine blanket-ban language.