HMS Prince of Wales was a 74-gun third rate ship of the line of the Royal Navy, launched on 4 June 1765 at Neyland. She was part of the of ships of the line designed by Sir Thomas Slade.
American Revolution: On 29 June 1777 captured American ship "Lord Camden" near Cape Finisterre, Spain. On 25 May 1778, under command of Captain Benjamin Hill, she captured American schooner "Duc de Choiseul" at (). The next day she captured American brig "Gardoqui" at ().
She was broken up in 1783.