Three ships of the Royal Navy have borne the name HMS Guadeloupe, after the island group of Guadeloupe:
- was a sloop in service in 1760 to October 1762. Condemned in Antigua.
- was a 28-gun sixth rate launched in 1763 and sunk to avoid capture in 1781. She was subsequently salvaged and recommissioned by the French.
- was a 16-gun sloop, formerly the French Nisus, which the Royal Navy captured in 1809 and sold in 1814.
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