Duc d'Aquitaine was a 64-gun East Indiaman of the Compagnie des Indes, launched in 1754. On 30 May 1757, she was captured by the Royal Navy and commissioned as the third rate HMS Duc D'Aquitaine. She foundered in 1761 and was lost.
The ship was long at the gundeck ( at the keel), with a beam of and a depth of . She was assessed at 1,358 tons Builder's Old Measurement, with a displacement of about 2,300 tons. Propulsion was by sails, and she was rigged as a full-rigged ship.
Provision was made for her to carry 64 guns. As built, she was armed with 4ÃÂ36-pounder guns and 16ÃÂ12-pounder guns, giving a broadside of 168 livres (). Her complement was 260, comprised eleven officers and 249 men. By 1757, she had been equipped with 50ÃÂ18-pounder guns, giving a broadside of 450 livres (). Her complement was now 493.
Duc d'Acquitaine was built by Nicholas Levasseur at Lorient, Brittany for the Compagnie des Indes. Her keel was laid in September 1753. She was launched on 22 July 1754 and commissioned in January 1755 under the command of capitaine d'Esquelen.
Duc d'Acquitaine was a casualty of the Seven Years' War. In May 1757, she departed from Lisbon, Portugal with orders to capture . During her cruise, she captured a British merchant brig, which was ransomed for ã200. On 30 May, she was captured off Ouessant, Brittany by and . Duc d'Acquitaine struck her colours after a 45-minute battle. She lost 50 crew, with 22 severely wounded and many more wounded. HMS Eagle lost ten crew with 32 wounded. HMS Medway had ten wounded.
Duc d'Acquitaine lost all her masts in the battle. She was taken to Plymouth Dockyard, Devon, Great Britain for assessment. On 23 June 1757, she was purchased by the Admiralty for ã12,310, keeping her name. She was placed under the command of Washington Shirley on 7 March 1758. Refitting was completed in April at a cost of ã4,596, 14s, 6d. She was now armed with 24ÃÂ24-pounder, 26ÃÂ12-pounder, 12ÃÂ6-pounder and 2ÃÂ9-pounder guns, giving a broadside of . Her complement was 590 men. On 5 June, she participated in the Raid on St Malo. Between December 1758 and March 1759, she was refitted at Plymouth Dockyard at a cost of ã14,543, 14s, 2d. She was placed under the command of captain Sir William Hewett on 29 January. HMS Duc d'Acquitaine departed for the East Indies on 14 April.
On 1 January 1761, HMS Duc d'Aquitaine was caught in a cyclone off Pondicherry, India She had been anchored and attempted to go out to sea, but was unable to and so reanchored. The storm overwhelmed her and she foundered; only 19 men survived. The same storm claimed four other warships as well. foundered in much the same manner as HMS Duc D'Aquitaine, and with a similar outcome. , , and were all driven onshore and wrecked.