HMS Drake was a member of the standardized 20-gun sixth rates built at the end of the 17th century. After commissioning, she was lost within three months on the Irish Coast in a storm on 20 December 1694.
She was the second vessel to be named Drake. The first was a 16-gun vessel launched at Deptford in 1653 and sold at Jamaica in 1691.
She was ordered in the Second Batch of eight ships to be built under contract from George Fowler of Rotherhithe. She was launched on 26 September 1694.
She was commissioned on 26 September 1694 under the command of Captain John Stapleton, RN.
HMS Drake was wrecked with the loss of all hands on the Irish Coast in a storm on 20 December 1694.