Gwynneville is an unincorporated community in Hanover Township, Shelby County, in the U.S. state of Indiana.
Gwynneville was platted in 1881, and named after O'Brien Gynne, a local businessman and landowner. A post office opened at Gwynneville in 1881. Gwynneville had its own high school until the school was discontinued around 1918.
The United States Census Bureau delineated Gwynneville as a census designated place in the 2022 American Community Survey.